abstract：:Reactive oxygen species (ROS) are implicated in the modulation of diverse processes including immune responses. To evaluate the effects of metabolic ROS produced by mitochondria on B-cell function and development, we created transgenic (Tg) mice expressing a phosphorylation-defective mutant of succinate dehydrogenase ...

journal_title：European journal of immunology

authors： Ogura M,Inoue T,Yamaki J,Homma MK,Kurosaki T,Homma Y

更新日期：2017-02-01 00:00:00

abstract：:Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune-related adverse events, most likely due to the breadth of the induced T-cell activation. Here, we investigated the efficacy of a local low-dose...

journal_title：European journal of immunology

authors： van Hooren L,Sandin LC,Moskalev I,Ellmark P,Dimberg A,Black P,Tötterman TH,Mangsbo SM

更新日期：2017-02-01 00:00:00

abstract：:A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-...

journal_title：European journal of immunology

authors： Sorobetea D,Holm JB,Henningsson H,Kristiansen K,Svensson-Frej M

更新日期：2017-02-01 00:00:00

abstract：:The outcomes of many diseases differ between women and men, with women experiencing a higher incidence and more severe pathogenesis of autoimmune and some infectious diseases. It has been suggested that this is partially due to activation of plasmacytoid dendritic cells (pDCs), the main producers of interferon (IFN)-α...

journal_title：European journal of immunology

authors： Ziegler SM,Beisel C,Sutter K,Griesbeck M,Hildebrandt H,Hagen SH,Dittmer U,Altfeld M

更新日期：2017-02-01 00:00:00

abstract：:The delivery of T-cell help to B cells is antigen-specific, MHC-restricted, and CD40L (CD154) dependent. It has been thought that when a T cell recognizes an antigen-presenting B cell, CD40L expressed on the T-cell surface engages with CD40 on the surface of B cells as long as the cells remain conjugated. By adding fl...

journal_title：European journal of immunology

authors： Gardell JL,Parker DC

更新日期：2017-01-01 00:00:00

abstract：:CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by ADAM17 (A disintegrin and metalloprotease 17). Here, we identified CSF1R as a major substrate of ADAM17 in an unbiased degradomics ...

journal_title：European journal of immunology

authors： Qing X,Rogers L,Mortha A,Lavin Y,Redecha P,Issuree PD,Maretzky T,Merad M,McIlwain D,Mak TW,Overall CM,Blobel CP,Salmon JE

更新日期：2016-12-01 00:00:00

abstract：:Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host response to Mycoba...

journal_title：European journal of immunology

authors： Lachmandas E,Beigier-Bompadre M,Cheng SC,Kumar V,van Laarhoven A,Wang X,Ammerdorffer A,Boutens L,de Jong D,Kanneganti TD,Gresnigt MS,Ottenhoff TH,Joosten LA,Stienstra R,Wijmenga C,Kaufmann SH,van Crevel R,Netea MG

更新日期：2016-11-01 00:00:00

abstract：:CD40-CD40 ligand (CD40L) signaling plays multiple indispensable roles in cellular and humoral immunity. Impaired memory T-cell responses in the absence of CD40L have been well documented, but the requirement of this interaction for efficient priming of CD8+ T cells especially under inflammatory conditions has been und...

journal_title：European journal of immunology

authors： Durlanik S,Loyal L,Stark R,Sercan Alp Ö,Hartung A,Radbruch A,von Herrath M,Matzmohr N,Frentsch M,Thiel A

更新日期：2016-11-01 00:00:00

abstract：:Atopic dermatitis (AD) or eczema is the most common chronic inflammatory skin disease. It is a multifactorial disease with local and systemic immune changes. Current therapies focus on restoring the local skin barrier or inhibiting immune responses. In this issue of the European Journal of Immunology, Sehra et al. [Eu...

journal_title：European journal of immunology

authors： Knol EF,Hijnen D

更新日期：2016-11-01 00:00:00

abstract：:While c-myc often contributes to the generation of B cell transformation, its transgenic overexpression alone does not lead to full transformation of B-lineage cells. Synergistically acting second genes must cooperate. Here, we constructed doxycycline-inducible cDNA-libraries from pre-B cell mRNA. These libraries were...

journal_title：European journal of immunology

authors： Wolf I,Bouquet C,Melchers F

更新日期：2016-11-01 00:00:00

abstract：:Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the un...

journal_title：European journal of immunology

authors： Pinti M,Appay V,Campisi J,Frasca D,Fülöp T,Sauce D,Larbi A,Weinberger B,Cossarizza A

更新日期：2016-10-01 00:00:00

abstract：:Upon antigen-specific or allogeneic activation, T cells sharply increase their metabolic activity to cope with augmented needs for proliferation and effector functions. Therefore, enzymes involved in energy metabolism constitute attractive targets to modulate the activity of pathogenic effector T cells in the setting ...

journal_title：European journal of immunology

authors： Raha S,Raud B,Oberdörfer L,Castro CN,Schreder A,Freitag J,Longerich T,Lochner M,Sparwasser T,Berod L,Koenecke C,Prinz I

更新日期：2016-09-01 00:00:00

abstract：:Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development in gut-associated lymphoid tissue species. Here we describe targeting of the immunoglobulin light chain locus by homologous recombination in chicken primordial germ cells (PGCs) and generati...

journal_title：European journal of immunology

authors： Schusser B,Collarini EJ,Pedersen D,Yi H,Ching K,Izquierdo S,Thoma T,Lettmann S,Kaspers B,Etches RJ,van de Lavoir MC,Harriman W,Leighton PA

更新日期：2016-09-01 00:00:00

abstract：:Treatment of systemic lupus erythematosus patients with epratuzumab (Emab), a humanized monoclonal antibody targeting CD22, leads to moderately reduced B-cell numbers but does not completely deplete B cells. Emab appears to induce immunomodulation of B cells, but the exact mode of action has not been defined. In the p...

journal_title：European journal of immunology

authors： Özgör L,Brandl C,Shock A,Nitschke L

更新日期：2016-09-01 00:00:00

abstract：:MicroRNAs control developmental pathways and effector functions in immune cells. Previous studies have studied the role of microRNAs in natural killer (NK) cells. However, the mouse models of microRNA depletion used were nonNK-specific and only partially depleting, hampering the interpretation of the data obtained. To...

journal_title：European journal of immunology

authors： Degouve S,Tavares A,Viel S,Walzer T,Marçais A

更新日期：2016-08-01 00:00:00

abstract：:Innate immunity, which is unable to discriminate self from allo-antigens, is thought to be important players in the induction of miscarriages. Here, we show that the administration of IL-12 to syngeneic-mated C57BL/6 mice on gestation day 7.5 (Gd 7.5), drives significant miscarriages in pregnant females. Furthermore, ...

journal_title：European journal of immunology

authors： Ichikawa T,Negishi Y,Shimizu M,Takeshita T,Takahashi H

更新日期：2016-08-01 00:00:00

abstract：:Postganglionic sympathetic neurons innervate secondary lymphoid organs and secrete norepinephrine (NE) as the primary neurotransmitter. NE binds and signals through five distinct members of the adrenergic receptor family. In this study, we show elevated expression of the β2-adrenergic receptor (ADRB2) on primary human...

journal_title：European journal of immunology

authors： Estrada LD,Ağaç D,Farrar JD

更新日期：2016-08-01 00:00:00

abstract：:Interleukin-12 family cytokines have emerged as critical regulators of immunity with some members (IL-12, IL-23) associated with disease pathogenesis while others (IL-27, IL-35) mitigate autoimmune diseases. Each IL-12 family member is comprised of an α and a β chain, and chain-sharing is a key feature. Although four ...

journal_title：European journal of immunology

authors： Wang X,Wei Y,Xiao H,Liu X,Zhang Y,Han G,Chen G,Hou C,Ma N,Shen B,Li Y,Egwuagu CE,Wang R

更新日期：2016-06-01 00:00:00

abstract：:Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to stud...

journal_title：European journal of immunology

authors： Li BW,de Bruijn MJ,Tindemans I,Lukkes M,KleinJan A,Hoogsteden HC,Hendriks RW

更新日期：2016-06-01 00:00:00

abstract：:FoxP3(+) Treg cells and anergic T cells are the two regulatory phenotypes of T-cell responses associated with helminth infection. Here, we examine the T-cell responses in mice during Fasciola hepatica infection, and to its tegumental coat antigens (FhTeg) that are shed from the fluke every 2-3 h. FhTeg comprises a ric...

journal_title：European journal of immunology

authors： Aldridge A,O'Neill SM

更新日期：2016-05-01 00:00:00

abstract：:Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process. However, Tfr-cell function in the GC is not well understood. Here, we define Tfr cells as a C...

journal_title：European journal of immunology

authors： Wu H,Chen Y,Liu H,Xu LL,Teuscher P,Wang S,Lu S,Dent AL

更新日期：2016-05-01 00:00:00

abstract：:Cells of the innate immune system build immunological memory via epigenetic reprogramming after stimulations with microbial ligands. This functional readjustment allows for enhanced nonspecific inflammatory responses upon secondary challenges, a process termed "trained immunity." The epigenomic blueprint of trained mo...

journal_title：European journal of immunology

authors： Crișan TO,Netea MG,Joosten LA

更新日期：2016-04-01 00:00:00

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00

abstract：:Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR-dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type-specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by the PRR NLRP3 in muri...

journal_title：European journal of immunology

authors： Chen KW,Bezbradica JS,Groß CJ,Wall AA,Sweet MJ,Stow JL,Schroder K

更新日期：2016-04-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the viru...

journal_title：European journal of immunology

authors： Remot A,Descamps D,Jouneau L,Laubreton D,Dubuquoy C,Bouet S,Lecardonnel J,Rebours E,Petit-Camurdan A,Riffault S

更新日期：2016-04-01 00:00:00

abstract：:Toll-like receptors (TLRs) are playing important roles in stimulating the innate immune response and intensifying adaptive immune response against invading pathogens. Appropriate regulation of TLR activation is important to maintain a balance between preventing tumor activation and inhibiting autoimmunity. Toll-like r...

journal_title：European journal of immunology

authors： Kim TW,Hong S,Talukder AH,Pascual V,Liu YJ

更新日期：2016-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) are innate immune receptors that respond to both exogenous and endogenous stimuli and are suggested to contribute to the perpetuation of chronic inflammation associated with rheumatoid arthritis (RA). In particular, the endosomal TLRs 3, 7, 8, and 9 have more recently been postulated to be o...

journal_title：European journal of immunology

authors： Sacre S,Lo A,Gregory B,Stephens M,Chamberlain G,Stott P,Brennan F

更新日期：2016-03-01 00:00:00

abstract：:Tissue factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium ...

journal_title：European journal of immunology

authors： Venkatasubramanian S,Tripathi D,Tucker T,Paidipally P,Cheekatla S,Welch E,Raghunath A,Jeffers A,Tvinnereim AR,Schechter ME,Andrade BB,Mackman N,Idell S,Vankayalapati R

更新日期：2016-02-01 00:00:00

abstract：:Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation. The synthesis, activation, and release of IL-1β are crucial for MSU-induced inflammation. The current st...

journal_title：European journal of immunology

authors： Amaral FA,Bastos LF,Oliveira TH,Dias AC,Oliveira VL,Tavares LD,Costa VV,Galvão I,Soriani FM,Szymkowski DE,Ryffel B,Souza DG,Teixeira MM

更新日期：2016-01-01 00:00:00

abstract：:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation cap...

journal_title：European journal of immunology

authors： Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

更新日期：2016-01-01 00:00:00

abstract：:Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative phosphorylation using pyruvate (derived from glucose and glycolysis) and fatty acids (FAs), both of which are oxidized in the Krebs cycle, as fuel sources. Mitochondria are also an important source of reactive oxygen species (ROS)...

journal_title：European journal of immunology

authors： Mills EL,O'Neill LA

更新日期：2016-01-01 00:00:00

abstract：:In hematopoietic stem cell transplantation (HSCT), when no HLA full-matched donor is available, alternative donors could include one HLA-mismatched donor. Recently, the low expressed HLA-C alleles have been identified as permissive mismatches for the best donor choice. Concerning HLA-A, the degree of variability of ex...

journal_title：European journal of immunology

authors： René C,Lozano C,Villalba M,Eliaou JF

更新日期：2015-12-01 00:00:00

abstract：:Transcription factors (TFs) regulate cell-type-specific gene expression programs by combinatorial binding to cis-genomic elements, particularly enhancers, subsequently leading to the recruitment of cofactors, and the general transcriptional machinery to target genes. Using data integration of genome-wide TF binding pr...

journal_title：European journal of immunology

authors： Fang Z,Hecklau K,Gross F,Bachmann I,Venzke M,Karl M,Schuchhardt J,Radbruch A,Herzel H,Baumgrass R

更新日期：2015-11-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneous candidiasis (CMC...

journal_title：European journal of immunology

authors： Zheng J,van de Veerdonk FL,Crossland KL,Smeekens SP,Chan CM,Al Shehri T,Abinun M,Gennery AR,Mann J,Lendrem DW,Netea MG,Rowan AD,Lilic D

更新日期：2015-10-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) are innate effectors playing an important role in the defense against helminthic infections and in the pathogenesis of allergic inflammation. Cytokines have been identified as the major stimuli driving ILC2 activation and expansion. Conversely, it is unclear whether costimulatory ...

journal_title：European journal of immunology

authors： Paclik D,Stehle C,Lahmann A,Hutloff A,Romagnani C

更新日期：2015-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a major part in providing innate immunity against pathogenic microorganisms. Recent studies show that these receptors are also expressed on T cells, which are the sentinels of adaptive immunity. Here, we have investigated the regulatory role of the T-cell receptor in the functioning of ...

journal_title：European journal of immunology

authors： Akhade AS,Qadri A

更新日期：2015-09-01 00:00:00

abstract：:Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses in intestinal infection models. Mice were held on iron-deficient, normal iron, or high iron di...

journal_title：European journal of immunology

authors： Kortman GA,Mulder ML,Richters TJ,Shanmugam NK,Trebicka E,Boekhorst J,Timmerman HM,Roelofs R,Wiegerinck ET,Laarakkers CM,Swinkels DW,Bolhuis A,Cherayil BJ,Tjalsma H

更新日期：2015-09-01 00:00:00

abstract：:Chronic skin inflammation resulting from a defective epidermal barrier is a hallmark of atopic dermatitis (AD). We previously demonstrated that mice lacking FGF receptors 1 and 2 in keratinocytes (K5-R1/R2 mice) develop an AD-like chronic dermatitis as a result of an impaired epidermal barrier. Here, we show that γδ T...

journal_title：European journal of immunology

authors： Sulcova J,Maddaluno L,Meyer M,Werner S

更新日期：2015-09-01 00:00:00

abstract：:Upon transplantation of T cells from a CD28 superagonist (CD28-SA) treated donor into an irradiated allogeneic host, the CD28-SA-induced activation and expansion of Treg cells inhibits acute graft versus host disease (aGvHD), while not abrogating the desired graft versus tumor effect. Human peripheral blood CD4(+) T c...

journal_title：European journal of immunology

authors： Beyersdorf N,Werner S,Wolf N,Hünig T,Kerkau T

更新日期：2015-07-01 00:00:00

abstract：:Reciprocal induction of the Th1 and Th17 immune responses is essential for optimal protection against Mycobacterium tuberculosis (Mtb); however, only a few Mtb antigens are known to fulfill this task. A functional role for resuscitation-promoting factor (Rpf) E, a latency-associated member of the Rpf family, in promot...

journal_title：European journal of immunology

authors： Choi HG,Kim WS,Back YW,Kim H,Kwon KW,Kim JS,Shin SJ,Kim HJ

更新日期：2015-07-01 00:00:00